CB1 Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release
Background: Endocannabinoids can affect pancreatic β cell physiology.
Results: Anandamide and 2-arachidonoylglycerol binding to CB1receptors induces focal adhesion kinase phosphorylation, which is a prerequisite of insulin release.
Conclusion: Focal adhesion kinase activation downstream from CB1receptors couples cytoskeletal reorganization to insulin release.
Significance: Identifies the molecular blueprint of 2-arachidonoylglycerol signaling in the endocrine pancreas, and outlines a kinase activation cascade linking endocannabinoid signals to insulin release.