Mouse over image to zoom 1983-1985 Honda CB 650 SC Nighthawk Kevlar Carbon Front Brake Pads

New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is applicable). Packaging should be the same as what is found in a retail store, unless the item was packaged by the manufacturer in non-retail packaging, such as an unprinted box or plastic bag. See the seller’s listing for full details

Vintage OWNER’S MANUAL 1980 HONDA CB650 Motorcycle CB 650 Book

Up for auction is this vintage OWNER’S MANUAL for HONDA 1980 CB650 Custom!

This booklet is full of helpful photos, diagrams and information with many pages of English and French Instructions!
This manual covers safety, operation, maintenance, specifications, cleaning, special procedures and lot’s more!!
The cover is unattached.
Don’t miss this find! Solid information for your machine!
Read it before you ride

Shipping will be $5.25 to the USA, $3 within Canada and $8 International.

Good Luck Bidding

Honda cb 750 best offer?

1971 cb750 daily rider,lots of new things.Look at pictures. Custom seat with flames..electronic ignition, newer coils off a 1976 cb750 supersport, cleaned and rejetted the carbuaters, jetting is as follows ,, idle jet is a 42,,main jet is a 130, Im running it this way because the 4 into 1 kerker header is running with only .

Honda cb 750 best offer?

1971 cb750 daily rider,lots of new things.Look at pictures. Custom seat with flames..electronic ignition, newer coils off a 1976 cb750 supersport, cleaned and rejetted the carbuaters, jetting is as follows ,, idle jet is a 42,,main jet is a 130, Im running it this way because the 4 into 1 kerker header is running with only ..

Suppression of outward K+ currents by win55212-2 in rat retinal ganglion cells is independent of CB1/CB2 receptors.

Cannabinoid CB1 receptor (CB1R) signaling system is extensively distributed in the vertebrate retina. Activation of CB1Rs regulates a variety of functions of retinal neurons through modulating different ion channels. In the present work we studied effects of this receptor signaling on K+ channels in retinal ganglion cells by patch-clamp techniques. The CB1R agonist WIN 55212-2 (WIN) suppressed outward K+ currents in acutely isolated rat retinal ganglion cells in a dose-dependent manner, with an IC50 of 4.7 μM. We further showed that WIN mainly suppressed the tetraethylammonium (TEA)-sensitive K+ current component. Whilst CB1Rs were expressed in rat retinal ganglion cells, the WIN effect on K+ currents was not blocked by either AM251/SR141716, specific CB1R antagonists, or AM630, a selective CB2R antagonist. Consistently, cAMP-protein kinase A (PKA) and mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) signaling pathways were unlikely involved in the WIN-induced suppression of the K+ currents because both PKA inhibitors H-89/Rp-cAMP and MAPK/ERK1/2 inhibitor U0126 failed to block the WIN effects. WIN-induced suppression of the K+ currents was not observed when WIN was intracellularly applied. Furthermore, an endogenous ligand of cannabinoid receptor anandamide (AEA), the specific CB1R agonist ACEA and the selective CB2R agonist CB65 also suppressed the K+ currents, and the effects were not blocked by AM251/SR141716 or AM630 respectively. All these results suggest that the WIN-induced suppression of the outward K+ currents in rat retinal ganglion cells, thereby regulating the cell excitability, were not through CB1R/CB2R signaling pathways.

Anti-Cancer Effects In Human Liver Cancer Cells Produced By Cannabis Agonists

According to preclinical data published online in the journal Toxicology Mechanisms and Methods, the administration of synthetic cannabinoid agonists minimizes cell viability in human hepacarcinoma cells and could be a potential option for treating liver cancer.

The anti-cancer properties of two synthetic cannabinoids, CB65 (CB2 receptor agonist) and ACEA (CB1 receptor agonist) in human hepacarcinoma cells were assessed by investigators from the Tehran University of Medical Sciences, Department of Toxicology and Pharmacology.

It was reported by the authors that the cannabinoid administration minimized malignant cell viability and cell invasion in a dose-dependent manner. “These data suggest ACEA and CB65 as an option for novel treatment of hepatocellular cancer,” they concluded.

Studies in the past have demonstrated that tumor cell growth is inhibited by cannabinoids that also inhibit selectively induced apoptosis by different cell signaling pathways in various types of malignant cells, including gliomas (brain cancers) and lymphomas, prostate, breast, lung, skin, and pancreatic cancer cells.

The study “Evaluation of Anti-invasion Effect of Cannabinoids on Human Hepatocarcinoma Cells,” is available in Toxicology Mechanisms and Methods.

The role of central CB2 cannabinoid receptors on food intake in neonatal chicks

Abstract
The endocannabinoids (ECBs) have diverse physiological functions including the regulation of food intake and metabolism. In mammals, ECBs regulate feeding primarily through the CB1 receptors within the brain whereas the CB2 receptors are primarily involved in the regulation of immune function by direct action on peripheral immune cells and central glia. The central effect of ECBs on feeding behavior has not been studied in non-mammalian species. Therefore, the present study investigated the effect of CB65, a selective CB2 receptors agonist, on food intake in the neonatal chicks. In addition, the effect of astressin, a CRF receptor antagonist, on CB65-induced food intake was also investigated. Intracerebroventricular injection of the CB65 (1.25 μg) increased the food intake at 30- and 60-min post-injection significantly as compared to the control group. Pretreatment with a selective CB2 receptor antagonist, AM630, but not astressin, significantly attenuated the CB65-induced food intake. These results suggested that CB2 receptor agonists act on the brain to induce food intake.

The role of central CB2 cannabinoid receptors on food intake in neonatal chicks.

ABSTRACT The endocannabinoids (ECBs) have diverse physiological functions including the regulation of food intake and metabolism. In mammals, ECBs regulate feeding primarily through the CB1 receptors within the brain whereas the CB2 receptors are primarily involved in the regulation of immune function by direct action on peripheral immune cells and central glia. The central effect of ECBs on feeding behavior has not been studied in non-mammalian species. Therefore, the present study investigated the effect of CB65, a selective CB2 receptors agonist, on food intake in the neonatal chicks. In addition, the effect of astressin, a CRF receptor antagonist, on CB65-induced food intake was also investigated. Intracerebroventricular injection of the CB65 (1.25 μg) increased the food intake at 30- and 60-min post-injection significantly as compared to the control group. Pretreatment with a selective CB2 receptor antagonist, AM630, but not astressin, significantly attenuated the CB65-induced food intake. These results suggested that CB2 receptor agonists act on the brain to induce food intake.

Study: Synthetic Cannabinoids Produce Anti-Cancer Effects In Human Liver Cancer Cells

As the debate continues in New Zealand about regulating the availability of products containing synthetic cannabinoids, a new study has shown two particular compounds exhibit anti-cancer effects in human liver cancer cells.

This report is from US NORML’s Paul Armentano.

Thursday, 11 October 2012

Study: Cannabis Agonists Produce Anti-Cancer Effects In Human Liver Cancer CellsTehran, Iran: The administration of synthetic cannabinoid agonists reduce cell viability in human hepacarcinoma cells and may be a potential option for the treatment of liver cancer, according to preclinical data published online in the journal Toxicology Mechanisms and Methods.

Investigators from the Tehran University of Medical Sciences, Department of Toxicology and Pharmacology assessed the anti-cancer properties of two synthetic cannabinoids, CB65 (CB2 receptor agonist) and ACEA (CB1 receptor agonist) in human hepacarcinoma cells.

Authors reported that the administration of cannabinoids reduced malignant cell viability and cell invasion in a dose-dependent manner. “These data suggest ACEA and CB65 as an option for novel treatment of hepatocellular cancer,” they concluded.

Previous studies have demonstrated that cannabinoids inhibit tumor cell growth and selectively induced apoptosis by different cell signaling pathways in various types of malignant cells, including gliomas (brain cancers) and lymphomas, prostate, breast, lung, skin, and pancreatic cancer cells.

For more information, please contact Paul Armentano, NORML Deputy Director, at: paul@norml.org. Full text of the study, “Evaluation of Anti-invasion Effect of Cannabinoids on Human Hepatocarcinoma Cells,” is available in Toxicology Mechanisms and Methods.

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